Cullin 7 anticorps (AbBy Fluor® 680)

N° du produit ABIN5000720

Cet anticorps anti-Cullin 7 est un anticorps Lapin Polyclonal détectant Cullin 7 dans WB et IF (p). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour Cullin 7 anticorps (AbBy Fluor® 680) (ABIN5000720)

Antigène: Cullin 7 (CUL7)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cullin 7 est conjugé à/à la AbBy Fluor® 680

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-Cullin 7 anticorps (AbBy Fluor® 680)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Cullin 7

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Cullin 7

Antigène: Cullin 7 (CUL7)

Autre désignation: Cullin 7

Sujet:

Synonyms: CUL-7, CUL7, CUL7_HUMAN, Cullin-7, dJ20C7.5, KIAA0076.

Background: Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity). Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity.Involvement in disease: Defects in CUL7 are the cause of 3M syndrome type 1 (3M1). An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies.

ID gène: 9820

Pathways: ER-Nucleus Signaling