KDM3A anticorps (N-Term)

N° du produit ABIN500074

Cet anticorps Lapin Polyclonal détecte spécifiquement KDM3A dans WB, IHC (p) et EIA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour KDM3A anticorps (N-Term) (ABIN500074)

Antigène: KDM3A (Lysine (K)-Specific Demethylase 3A (KDM3A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDM3A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-KDM3A anticorps

Épitope: N-Term

Specificité: This antibody detects KDM3A / JHDM2A. It will not cross-react with JMJD1B or JMJD1C.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: JMJD1A antibody was raised against a 16 amino acid peptide from near the amino terminus of human JMJD1A.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur KDM3A

Antigène: KDM3A (Lysine (K)-Specific Demethylase 3A (KDM3A))

Autre désignation: KDM3A / JHDM2A

Sujet: The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. JMJD1A is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of STAT3, a protein that has been found to be important in the maintenance of mouse embryonic stem (mES) cells, and decreased JMJD1A expression correlated with the differentiation of cultured mES cells following the removal of the cytokine LIF. These findings suggest that JMJD1A might be a critical signaling molecule underlying the maintenance of pluripotency in embryonic stem cells. At least two isoforms of JMJD1A are known to exist.Synonyms: JMJD1, JMJD1A, JmjC domain-containing histone demethylation protein 2A, Jumonji domain-containing protein 1A, KIAA0742, Lysine-specific demethylase 3A, TSGA

ID gène: 55818

NCBI Accession: NP_060903

UniProt: Q9Y4C1

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, L'effet Warburg