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PALB2 anticorps (C-Term)
PALB2
Reactivité: Humain, Souris, Rat
WB, EIA
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-PALB2 anticorps
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Antigène
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PALB2
(Partner and Localizer of BRCA2 (PALB2))
Épitope
Tous les épitopes à travers PALB2 Anticorps.
C-Term
Reactivité
Toutes les réactivités sur PALB2 Anticorps
Humain, Souris, Rat
Hôte
Toutes les hôtes sur PALB2 Anticorps
Lapin
Clonalité
Toutes les clonalités sur PALB2 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers PALB2 Anticorps
Cet anticorp PALB2 est non-conjugé
Application
Tous les applications à travers PALB2 Anticorps.
Western Blotting (WB), Enzyme Immunoassay (EIA)
Specificité
This antibody detects PALB2.
Réactivité croisée (Details)
Species reactivity (tested):Human, mouse, rat
Purification
Peptide affinity chromatography
Immunogène
PALB2 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human PALB2.
Isotype
IgG
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Information d'application
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Indications d'application
ELISA. Western blot: 1 - 2 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Stockage
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Buffer
PBS containing 0.02 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Références pour anticorps anti-PALB2 (ABIN500447)
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Loke, Pearlman, Upadhyay, Tesfa, Shao, Ostrer : "Functional variant analyses (FVAs) predict pathogenicity in the BRCA1 DNA double-strand break repair pathway. " dans: Human molecular genetics , Vol. 24 , Issue 11 , pp. 3030-7 , (2016 ) (PubMed ).
Détails sur PALB2
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Antigène
PALB2
(Partner and Localizer of BRCA2 (PALB2))
Autre désignation
PALB2 (PALB2 Produits )
Sujet
The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.Synonyms: FANCN, Partner and localizer of BRCA2
ID gène
79728
UniProt
Q86YC2
Pathways
Réparation de l'ADN
Vus récemment
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