KAT5 anticorps (AA 51-150) (AbBy Fluor® 680)

N° du produit ABIN5005739

Cet anticorps anti-KAT5 est un anticorps Lapin Polyclonal détectant KAT5 dans WB, IF (cc) et IF (p). Adapté pour Souris et Rat.

Aperçu rapide pour KAT5 anticorps (AA 51-150) (AbBy Fluor® 680) (ABIN5005739)

Antigène: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KAT5 est conjugé à/à la AbBy Fluor® 680

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-KAT5 anticorps (AbBy Fluor® 680)

Épitope: AA 51-150

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human KAT5 / Tip60

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur KAT5

Antigène: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Autre désignation: KAT5 / Tip60

Sujet:

Synonyms: 60 kDa Tat interactive protein, 60 kDa Tat-interactive protein, cPLA2 interacting protein, cPLA2-interacting protein, cPLA2, cPLA2 interacting protein, ESA1, Histone acetyltransferase HTATIP, Histone acetyltransferase KAT5, HIV 1 Tat interactive protein, HIV 1 Tat interactive protein, 60 kDa, HIV-1 Tat interactive protein, HTATIP, HTATIP1, Klysine acetyltransferase 5, K-acetyltransferase 5, KAT5, KAT5_HUMAN, Lysine acetyltransferase 5, PLIP, Tat interacting protein, 60 kDa, TIP, Tip60.

Background: MOZ (monocytic leukemia zinc finger protein) is a chromatin-associated histone acetyltransferase (HAT) that regulates chromatin remodeling and transcription. The MOZ gene was initially isolated as a consequence of two variant translocations that were identified in a distinct subtype of acute myeloid leukemias and resulted in the formation of MOZ fusion proteins. These fusions involve the HAT domain of MOZ with the activation domain of either transcriptional coactivator protein TIF2/GRIP1 or CBP, and lead to enhanced transcriptional activation by a mechanism involving aberrant histone acetylation. Additional MOZ related proteins, including MORF (MOZ related factor) and TIP60 (TAT interacting proteins 60), share significant similarities with MOZ including the putuative HAT domain. MORF also contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at the C terminus, suggesting that MORF has both HAT activity and contributes to the regulation of transcriptional activation. TIP60 was originally identified as a coactivator for the HIV TAT protein and also functions as a nuclear hormone receptor coactivator that enhances ligand dependent steroid receptor-mediated transactivation involving the androgen, estrogen and progesterone receptors.

UniProt: Q92993

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway