RHEB anticorps (Center)

N° du produit ABIN500597

L’anticorps Lapin Polyclonal anti-RHEB a été validé pour WB, IHC (p) et EIA. Il convient pour détecter RHEB dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour RHEB anticorps (Center) (ABIN500597)

Antigène: RHEB (Ras Homolog Enriched in Brain (RHEB))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RHEB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-RHEB anticorps

Épitope: Center

Specificité: This antibody detects Rheb at center.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: Rheb antibody was raised against a 15 amino acid peptide from the middle region of human Rheb.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 μg/mL. Immunohistochemistry on paraffin sections
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur RHEB

Antigène: RHEB (Ras Homolog Enriched in Brain (RHEB))

Autre désignation: RHEB

Sujet: Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure (1). While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway (2). Biochemical and genetic studies demon-strate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway (3-5). TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2 (3).Synonyms: GTP-binding protein Rheb, RHEB2, Ras homolog enriched in brain

ID gène: 6009

UniProt: Q15382

Pathways: Signalisation RTK