RIPK3 anticorps (AA 473-486)

N° du produit ABIN500612

L’anticorps Lapin Polyclonal anti-RIPK3 a été validé pour WB, IHC (p), IF et EIA. Il convient pour détecter RIPK3 dans des échantillons de Souris et Rat.

Aperçu rapide pour RIPK3 anticorps (AA 473-486) (ABIN500612)

Antigène: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RIPK3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-RIPK3 anticorps

Épitope: AA 473-486

Specificité: This antibody detects RIP3.

Réactivité croisée (Details): Species reactivity (tested):Mouse, Rat.

Purification: Peptide Affinity Chromatography

Immunogène: RIP3 antibody was raised against a peptide corresponding to amino acids 473 to 486 of Murine RIP3.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 to 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, 0.02 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur RIPK3

Antigène: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Autre désignation: RIPK3 / RIP3

Sujet: Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3 (1-3). RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Overexpression of RIP3 induces apoptosis and NF-kappaB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues (2,3).Synonyms: RIP-3, RIP-like protein kinase 3, Receptor-interacting protein 3, Receptor-interacting serine/threonine-protein kinase 3

Poids moléculaire: 57 kDa

ID gène: 56532

UniProt: Q9QZL0

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades