SKIL anticorps (N-Term)
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- Antigène Voir toutes SKIL Anticorps
- SKIL (SKI-Like Oncogene (SKIL))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SKIL est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Specificité
- This antibody detects SKIL / SnoN. It will recognize all isoforms (SnoN, SnoN2, SnoI, and SnoA).
- Réactivité croisée (Details)
- Species reactivity (tested):Human, mouse, rat
- Purification
- Peptide affinita chromatography
- Immunogène
- SnoN antibody was raised against a 16 amino acid peptide from near the amino terminus of human SnoN.
- Isotype
- IgG
- Top Product
- Discover our top product SKIL Anticorps primaire
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- Indications d'application
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ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Antigène
- SKIL (SKI-Like Oncogene (SKIL))
- Autre désignation
- SKIL / SnoN (SKIL Produits)
- Synonymes
- anticorps SNO, anticorps SnoA, anticorps SnoI, anticorps SnoN, anticorps Skir, anticorps Sno, anticorps SKIL, anticorps DKFZp459L122, anticorps sno, anticorps zgc:193698, anticorps SKI like proto-oncogene, anticorps SKI-like proto-oncogene, anticorps ski-like protein, anticorps SKI-like, anticorps SKI-like proto-oncogene b, anticorps SKIL, anticorps Skil, anticorps LOC100010058, anticorps skil, anticorps skilb
- Sujet
- TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells. There are at least four alternately spliced isoforms of SnoN.Synonyms: SNO, Ski-like protein, Ski-related novel protein N, Ski-related oncogene, Ski-related protein, SnoA, Snol
- ID gène
- 6498
- NCBI Accession
- NP_005405
- UniProt
- P12757
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
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