NUMA1 anticorps (pSer395) (AbBy Fluor® 750)

N° du produit ABIN5007942

Cet anticorps Lapin Polyclonal détecte spécifiquement NUMA1 dans IF (p) et IF (cc). Il présente une réactivité envers Humain.

Aperçu rapide pour NUMA1 anticorps (pSer395) (AbBy Fluor® 750) (ABIN5007942)

Antigène: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUMA1 est conjugé à/à la AbBy Fluor® 750

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Détail du produit anti-NUMA1 anticorps (AbBy Fluor® 750)

Épitope: pSer395

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human NuMA around the phosphorylation site of Ser395

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur NUMA1

Antigène: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Autre désignation: NuMA

Sujet:

Synonyms: NUMA 1, NuMA protein, NUMA1, SP H antigen, Structural nuclear protein, Centrophilin stabilizes mitotic spindle in mitotic cells, Nuclear mitotic apparatus protein 1, Nuclear mitotic apparatus protein.

Background: NuMA (Nuclear Mitotic Apparatus Protein) is an intranuclear protein and present in nucleus during interphase. At the onset of mitosis, it redistributes from the nucleus to two centrosomal structures that later will become part of the mitotic spindle pole. After anaphase, the protein redistributes from the spindle polar region into reforming nucleus. NuMA is an essential protein during mitosis for the terminal phases of chromosome separation and/or nuclear reassembly. Recently a study shows that NuMA is cleaved to a 180 to 200 kDa during apoptosis.

ID gène: 4926

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, M Phase