TAB1 anticorps (Center)

N° du produit ABIN500859

Cet anticorps anti-TAB1 Polyclonal Lapin (ABIN500859) détecte spécifiquement TAB1 dans WB, IF et EIA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour TAB1 anticorps (Center) (ABIN500859)

Antigène: TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TAB1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-TAB1 anticorps

Épitope: Center

Specificité: This antibody detects TAB1 / MAP3K7IP1.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Peptide affinity chromatography

Immunogène: TAB1 antibody was raised against a synthetic peptide corresponding to 13 amino acids in the center of human TAB1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 to 1 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur TAB1

Antigène: TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))

Autre désignation: TAB1 / MAP3K7IP1

Sujet: TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7 (1), which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta and members of the Toll-IL-1R (TIR) superfamily (2), thus acting as an intermediate in both proliferative and innate and adaptive immune responses (3). This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals (4,5). It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-beta, demonstrating how this protein can function as a mediator between TGF-beta receptors and TAK1 (6).Synonyms: Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TAK1-binding protein 1, TGF-beta-activated kinase 1-binding protein 1

ID gène: 10454

NCBI Accession: NP_006107

Pathways: Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades