ANO1 anticorps (N-Term)

N° du produit ABIN500970

Cet anticorps anti-ANO1 est un anticorps Lapin Polyclonal détectant ANO1 dans IF, WB et EIA. Adapté pour Humain et Souris.

Aperçu rapide pour ANO1 anticorps (N-Term) (ABIN500970)

Antigène: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ANO1 est non-conjugé

Application: Immunofluorescence (IF), Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-ANO1 anticorps

Épitope: N-Term

Specificité: At least three isoforms are known to exist. This antibody will not cross-react with TMEM16B.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: Peptide affinity chromatography

Immunogène: 17 amino acid peptide from near the amino terminus of Human TMEM16A

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ANO1

Antigène: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Autre désignation: ANO1 / DOG1

Sujet: Calcium-activated chloride channels (CaCC) are present in many cell types and mediate physiological functions such as epithelial secretion, sensory signal transduction, and smooth muscle contraction. Subunits of these CaCC's include the transmembrane proteins TMEM16A and TMEM16B. TMEM16A is expressed in epithelial cells of the kidney and lung, pancreas, and sensory neurons and its mRNA is seen in foregut, airway epithelia, and tracheal smooth muscle, mice lacking TMEM16A fail to survive past ten days and show aerophagia and little weight gain. TMEM16A is also overexpressed or amplified in multiple cancers associated with poor survival such as oral cancers and gastrointestinal stromal tumors, suggesting the development of CaCC modulators may be a viable therapeutic strategy.Synonyms: Anoctamin-1, DOG-1, Discovered on gastrointestinal stromal tumors protein 1, ORAOV2, Oral cancer overexpressed protein 2, TAOS2, TMEM16A, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2

ID gène: 55107

NCBI Accession: NP_060513