ANO1 anticorps (N-Term)
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- Antigène Voir toutes ANO1 Anticorps
- ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
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Épitope
- N-Term
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ANO1 est non-conjugé
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Application
- Immunofluorescence (IF), Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificité
- At least three isoforms are known to exist. This antibody will not cross-react with TMEM16B.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, Mouse.
- Purification
- Peptide affinity chromatography
- Immunogène
- 17 amino acid peptide from near the amino terminus of Human TMEM16A
- Isotype
- IgG
- Top Product
- Discover our top product ANO1 Anticorps primaire
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- Indications d'application
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ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 0.02 % Sodium Azide as preservative
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
- Autre désignation
- ANO1 / DOG1 (ANO1 Produits)
- Synonymes
- anticorps DOG1, anticorps ORAOV2, anticorps TAOS2, anticorps TMEM16A, anticorps Tmem16a, anticorps anoctamin 1, anticorps anoctamin 1, calcium activated chloride channel, anticorps Ano1, anticorps ANO1
- Sujet
- Calcium-activated chloride channels (CaCC) are present in many cell types and mediate physiological functions such as epithelial secretion, sensory signal transduction, and smooth muscle contraction. Subunits of these CaCC's include the transmembrane proteins TMEM16A and TMEM16B. TMEM16A is expressed in epithelial cells of the kidney and lung, pancreas, and sensory neurons and its mRNA is seen in foregut, airway epithelia, and tracheal smooth muscle, mice lacking TMEM16A fail to survive past ten days and show aerophagia and little weight gain. TMEM16A is also overexpressed or amplified in multiple cancers associated with poor survival such as oral cancers and gastrointestinal stromal tumors, suggesting the development of CaCC modulators may be a viable therapeutic strategy.Synonyms: Anoctamin-1, DOG-1, Discovered on gastrointestinal stromal tumors protein 1, ORAOV2, Oral cancer overexpressed protein 2, TAOS2, TMEM16A, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2
- ID gène
- 55107
- NCBI Accession
- NP_060513
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