TICAM1 anticorps (C-Term)

N° du produit ABIN501042

Cet anticorps anti-TICAM1 Polyclonal Lapin (ABIN501042) détecte spécifiquement TICAM1 dans WB, IHC (p) et EIA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour TICAM1 anticorps (C-Term) (ABIN501042)

Antigène: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TICAM1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-TICAM1 anticorps

Épitope: C-Term

Specificité: This antibody detects TICAM1 / TRIF.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Ion exchange chromatography

Immunogène: TRIF antibody was raised against a peptide corresponding to 14 amino acids near the C- terminus of human TRIF.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 2 to 4 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur TICAM1

Antigène: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Autre désignation: TICAM1 / TRIF

Sujet: TRIF is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TRIF, along with other molecules such as TIRP, TIRAP, and MyD88, serves as an adaptor protein to several of the TLR molecules. Following activation of TLR3 and TLR4, TRIF engages the kinase TBK1 and allows its subsequent activation of the interferon regulatory factor (IRF)-3 (5). TRIF is also involved in the activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kappaB (6).Synonyms: PRVTIRB, Proline-rich vinculin and TIR domain-containing protein B, Putative NF-kappa-B-activating protein 502H, TICAM-1, TIR domain-containing adapter molecule 1, Toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta

ID gène: 148022

NCBI Accession: NP_891549

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades