TRIM5 anticorps (C-Term, Isoform alpha)

N° du produit ABIN501054

Cet anticorps anti-TRIM5 Polyclonal Lapin (ABIN501054) détecte spécifiquement TRIM5 dans WB, IF et EIA. L’anticorps est réactif avec des échantillons de Humain et Macaque rhésus.

Aperçu rapide pour TRIM5 anticorps (C-Term, Isoform alpha) (ABIN501054)

Antigène: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Reactivité: Humain, Macaque rhésus

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM5 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-TRIM5 anticorps

Épitope: C-Term, Isoform alpha

Specificité: This antibody detects TRIM5 / RNF88 at C-term.

Réactivité croisée (Details): Species reactivity (expected):Rhesus monkeySpecies reactivity (tested):Human

Purification: Paptide affinity chromatography

Immunogène: TRIM5 alpha antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of rhesus monkey TRIM5 alpha.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Immunoflourescence. Western blot: 1 to 2 μg/mL. A band at approximately 55 kDa can be detected.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur TRIM5

Antigène: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Autre désignation: TRIM5 / RNF88

Sujet: TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region (1). TRIM5 has six alternately spliced isoforms, the longest of which is the ? variant which also contains a carboxy-terminal B30.2 (SPRY) domain (1). Expression of TRIM5alpha variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1 (2,3), albeit at differing efficiencies. All TRIM5alpha variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5alpha acts as a natural barrier to cross-species retrovirus transmission (3).Synonyms: RING finger protein 88, Tripartite motif-containing protein 5

ID gène: 85363

NCBI Accession: NP_149023

Pathways: Activation of Innate immune Response