TSC1 anticorps (both Isoforms, Middle Region)

N° du produit ABIN501071

L’anticorps Lapin Polyclonal anti-TSC1 a été validé pour WB, IF et EIA. Il convient pour détecter TSC1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TSC1 anticorps (both Isoforms, Middle Region) (ABIN501071)

Antigène: TSC1 (Tuberous Sclerosis 1 (TSC1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TSC1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-TSC1 anticorps

Épitope: both Isoforms, Middle Region

Specificité: This antibody detects TSC1 / Hamartin at Center.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: TSC1 antibody was raised against a 15 amino acid peptide from the middle region of human TSC1. TSC1 antibody will recognize both isoforms of TSC1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur TSC1

Antigène: TSC1 (Tuberous Sclerosis 1 (TSC1))

Autre désignation: TSC1 / Hamartin

Sujet: Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 1,2). TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high (3). Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro (4), suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth (4,5). A shorter 40 kDa isoform of TSC1 has been shown to exist but its function is unknown.Synonyms: KIAA0243, TSC, Tuberous sclerosis 1 protein

ID gène: 7248

Pathways: Signalisation RTK, AMPK Signaling, Regulation of Cell Size, Tube Formation