CLEC4E anticorps

N° du produit ABIN5026978

Détail du produit anti-CLEC4E anticorps

Antigène: CLEC4E (C-Type Lectin Domain Family 4, Member E (CLEC4E))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CLEC4E est non-conjugé

Application: Western Blotting (WB)

Purification: Protein G Chromatography

Immunogène: A full length human CLEC4E protein was used as the immunogen for this antibody.

Clone: ABM42C6

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur CLEC4E

Antigène: CLEC4E (C-Type Lectin Domain Family 4, Member E (CLEC4E))

Autre désignation: CLEC4E (CLEC4E Produits)

Synonymes: anticorps CLECSF9, anticorps MINCLE, anticorps C86253, anticorps Clecsf9, anticorps Mincle, anticorps CLEC4E, anticorps C-type lectin domain family 4 member E, anticorps C-type lectin domain family 4, member e, anticorps C-type lectin domain family 4, member E, anticorps CLEC4E, anticorps Clec4e, anticorps LOC611538

Sujet: CLEC4E (C-type lectin domain family 4, member E), also called as Mincle, is a type II transmembrane C-type lectin receptor that specifically binds to the cord factor TDM (trehalose-6,6-dimycolate), a unique glycolipid of mycobacterial cell-surface components, and activates immune cells to confer adjuvant activity. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. CLEC4E is mainly expressed in myeloid cells, such as macrophages and neutrophils and possesses a single carbohydrate-recognition domain (CRD) in the extracellular region. It is associated with FcRgamma chain, an immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor, and acts as an activating receptor that senses damaged cells. CLEC4E is also a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPbeta) and may play a role in inflammation.

Poids moléculaire: 25 kDa

ID gène: 26253

UniProt: Q9ULY5