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GCET2 anticorps

GCET2 Reactivité: Humain IHC Hôte: Souris Monoclonal ABM43E6 unconjugated
N° du produit ABIN5026982
  • Antigène Voir toutes GCET2 Anticorps
    GCET2 (Germinal Center Expressed Transcript 2 (GCET2))
    Reactivité
    • 22
    • 15
    Humain
    Hôte
    • 30
    • 7
    Souris
    Clonalité
    • 31
    • 6
    Monoclonal
    Conjugué
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GCET2 est non-conjugé
    Application
    • 23
    • 13
    • 13
    • 10
    • 3
    • 3
    • 3
    • 2
    Immunohistochemistry (IHC)
    Purification
    Protein G Chromatography
    Immunogène
    A full length human HGAL protein was used as the immunogen for this antibody
    Clone
    ABM43E6
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product GCET2 Anticorps primaire
  • Indications d'application
    IHC: 5 μg/mL
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    PBS containing 0.05 % BSA, PH 7.4
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
  • Antigène
    GCET2 (Germinal Center Expressed Transcript 2 (GCET2))
    Autre désignation
    HGAL (GCET2 Produits)
    Synonymes
    anticorps Gcet, anticorps Gcet2, anticorps M17, anticorps M17-L, anticorps GCAT2, anticorps GCET2, anticorps HGAL, anticorps germinal center associated, signaling and motility, anticorps germinal center associated signaling and motility, anticorps germinal center-associated, signaling and motility, anticorps Gcsam, anticorps GCSAM
    Sujet
    Human germinal center-associated lymphoma (HGAL) is specifically expressed only in germinal center (GC), B lymphocytes and GC-derived lymphomas. It is located on chromosome 3q13, comprises 6 exons and encodes a cytoplasmic protein of 178 amino acids that contains an immunoreceptor tyrosine-based activation motif (ITAM). HGAL decreases lymphocyte motility by inhibiting the ability of myosin to translocate actin via direct interaction with F-actin and myosin II and by activating RhoA signaling via direct interactions with RhoA-specific guanine nucleotide exchange factors. It also regulates B-cell receptor (BCR) signaling by directly binding to and enhancing Syk kinase activity and activation of its downstream effectors (Ref-1). HGAL expression by tumor cells correlates with a favorable prognosis in patients with diffuse large B-cell and classical Hodgkin lymphomas.
    ID gène
    257144
    UniProt
    Q8N6F7
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