14-3-3 theta anticorps (AA 20-225)

N° du produit ABIN5027003

Cet anticorps anti-14-3-3 theta est un anticorps Lapin Polyclonal détectant 14-3-3 theta dans WB. Adapté pour Humain.

Aperçu rapide pour 14-3-3 theta anticorps (AA 20-225) (ABIN5027003)

Antigène: 14-3-3 theta (YWHAQ)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp 14-3-3 theta est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-14-3-3 theta anticorps

Épitope: AA 20-225

Purification: Protein A Chromatography

Immunogène: A partial length recombinant 14-3-3 protein (amino acids 20-225) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur 14-3-3 theta

Antigène: 14-3-3 theta (YWHAQ)

Autre désignation: YWHAQ

Sujet: YWHAQ, also known as 14-3-3 tau (14-3-3tau) is a a phosphoserine-binding protein and a member of the 14-3-3 family of proteins. The 14-3-3 family members are dimeric phosphoserine/ phosphothreonine-binding proteins, which are involved in a very diverse spectrum of signaling pathways. YWHAQ plays a critical role in the regulation of E2F1 stability. It binds to Ser31-phosphorylated E2F1 and inhibits the ubiquitination of E2F1 during DNA damage. The binding of YWHAQ to E2F1 interferes with the function of an E31 ligase and therefore inhibits the ubiquitination and degradation of E2F1. This interaction is required for the expression and induction of several E2F1 apoptotic target genes as well as apoptosis during DNA damage.

Poids moléculaire: 29 kDa

ID gène: 10971

UniProt: P27348

Pathways: Apoptose, Myometrial Relaxation and Contraction