14-3-3 theta anticorps (AA 20-225)

N° du produit ABIN5027003

Détail du produit anti-14-3-3 theta anticorps

Antigène: 14-3-3 theta (YWHAQ)

Épitope: AA 20-225

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp 14-3-3 theta est non-conjugé

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogène: A partial length recombinant 14-3-3 protein (amino acids 20-225) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur 14-3-3 theta

Antigène: 14-3-3 theta (YWHAQ)

Autre désignation: YWHAQ (YWHAQ Produits)

Synonymes: anticorps 14-3-3, anticorps 14-3-3t, anticorps 1c5, anticorps hs1, anticorps 1C5, anticorps HS1, anticorps 2700028P07Rik, anticorps AA409740, anticorps AU021156, anticorps R74690, anticorps ywhaq, anticorps ywhaq2, anticorps wu:fa91b01, anticorps wu:fb02e12, anticorps wu:fb36f06, anticorps wu:fk86h02, anticorps ywhaq1, anticorps ywhaz, anticorps zgc:55499, anticorps tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta, anticorps tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta, anticorps tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta S homeolog, anticorps tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a, anticorps 14-3-3 protein theta, anticorps tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b, anticorps YWHAQ, anticorps ywhaq, anticorps Ywhaq, anticorps ywhaq.S, anticorps ywhaqa, anticorps ywhaqb

Sujet: YWHAQ, also known as 14-3-3 tau (14-3-3tau) is a a phosphoserine-binding protein and a member of the 14-3-3 family of proteins. The 14-3-3 family members are dimeric phosphoserine/ phosphothreonine-binding proteins, which are involved in a very diverse spectrum of signaling pathways. YWHAQ plays a critical role in the regulation of E2F1 stability. It binds to Ser31-phosphorylated E2F1 and inhibits the ubiquitination of E2F1 during DNA damage. The binding of YWHAQ to E2F1 interferes with the function of an E31 ligase and therefore inhibits the ubiquitination and degradation of E2F1. This interaction is required for the expression and induction of several E2F1 apoptotic target genes as well as apoptosis during DNA damage.

Poids moléculaire: 29 kDa

ID gène: 10971

UniProt: P27348

Pathways: Apoptose, Myometrial Relaxation and Contraction