BRD4 anticorps (AA 140-500)

N° du produit ABIN5027061

Cet anticorps Lapin Polyclonal détecte spécifiquement BRD4 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour BRD4 anticorps (AA 140-500) (ABIN5027061)

Antigène: BRD4 (Bromodomain Containing 4 (BRD4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRD4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-BRD4 anticorps

Épitope: AA 140-500

Purification: Protein A Chromatography

Immunogène: A partial length recombinant BRD4 protein (amino acids 140-500) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 2-4 μg/mL This antibody detects ~80 kDa band. The size corresponds to Isoform 2 (Uniprot ID-O60885-2) of BRD4, HUNK1, the right size is ~152 kDa O60885 O60885

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur BRD4

Antigène: BRD4 (Bromodomain Containing 4 (BRD4))

Autre désignation: BRD4, HUNK1

Sujet: BRD4 is a member of the BET (bromo domain and extra terminal domain) family, along with BRD2, BRD3 and BRDT. BRD4 is required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II. A chromosomal aberration involving BRD4 is found in a rare, aggressive and lethal carcinoma arising in midline organs of young people. It expressed ubiquitously and has three isoforms. Isoform B acts as a chromatin insulator in the DNA damage response pathway.

Poids moléculaire: 88 kDa

ID gène: 23476

UniProt: O60885

Pathways: Chromatin Binding, SARS-CoV-2 Protein Interactome