MME anticorps (AA 282-496)

N° du produit ABIN5027077

Détail du produit anti-MME anticorps

Antigène: MME (Membrane Metallo-Endopeptidase (MME))

Épitope: AA 282-496

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MME est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Protein G Chromatography

Immunogène: A partial length recombinant CD10 protein (amino acids 282-496) was used as the immunogen for this antibody.

Clone: ABM4A52

Isotype: IgG2b kappa

Information d'application

Indications d'application: WB: 0.5-1 μg/mL, IHC: 5-10 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur MME

Antigène: MME (Membrane Metallo-Endopeptidase (MME))

Autre désignation: CD10 (MME Produits)

Synonymes: anticorps CALLA, anticorps CD10, anticorps NEP, anticorps SFE, anticorps 6030454K05Rik, anticorps C85356, anticorps Nep, anticorps neprilysin, anticorps membrane metalloendopeptidase, anticorps membrane metallo endopeptidase, anticorps membrane metallo-endopeptidase, anticorps MME, anticorps Mme

Classe de substances: Chemical

Sujet: CD10, also known as membrane metalloendopeptidase, neutral endopeptidase, neprilysin and common acute lymphoblastic leukaemia antigen (CALLA), is a zinc-dependent metalloendoprotease that cleaves signaling peptides. It is widely expressed in various normal tissues and in epithelial, stromal or both components of various malignancies. CD10 is a marker for intestinal epithelial brush border. It is also present in normal bile ducts and gallbladder epithelia but is absent in cholangiocarcinomas. It is con-sidered as the prototype of this family of membrane-bound, zinc-dependent endopeptidases, which regulate the physiological action of various peptides by lowering their extracellular concentration available for receptor binding. CD10 is also known to be an amyloid b-peptide (Ab) degrading enzyme. Polymorphisms in the CD10 gene increase the risk for Alzheimer disease. Outside the nervous system, it is present on the surface of neutrophils and regulates their activation by degradation of in ammatory peptides.

Poids moléculaire: 97 kDa

ID gène: 4311

UniProt: P08473

Pathways: Signalisation RTK, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration