OTUD5 anticorps (AA 300-520)

N° du produit ABIN5027170

Détail du produit anti-OTUD5 anticorps

Antigène: OTUD5 (OTU Domain Containing 5 (OTUD5))

Épitope: AA 300-520

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OTUD5 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Souris

Purification: Protein A Chromatography

Immunogène: A partial length recombinant DUBA protein (amino acids 300-520) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur OTUD5

Antigène: OTUD5 (OTU Domain Containing 5 (OTUD5))

Autre désignation: DUBA (OTUD5 Produits)

Synonymes: anticorps DUBA, anticorps AA407879, anticorps AI553596, anticorps BB114028, anticorps DXImx46e, anticorps Sfc7, anticorps otud5, anticorps si:bz30i22.1, anticorps si:rp71-30i22.1, anticorps zgc:154072, anticorps wu:fi28a06, anticorps zgc:100839, anticorps OTU deubiquitinase 5, anticorps OTU domain containing 5, anticorps OTU deubiquitinase 5a, anticorps OTU deubiquitinase 5 S homeolog, anticorps OTU deubiquitinase 5 L homeolog, anticorps OTU deubiquitinase 5b, anticorps OTUD5, anticorps Otud5, anticorps otud5a, anticorps otud5.S, anticorps otud5.L, anticorps otud5b

Sujet: DUBA belongs to a subfamily of 14 DUBs characterized by an OTU (Ovarian Tumor) domain. This protein suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. DUBA forms a direct complex with p53 and controls level of ubiquitination. The function of DUBA is required to allow the rapid activation of p53-dependent transcription and a p53-dependent apoptosis in response to DNA damage stress.

Poids moléculaire: 62 kDa

ID gène: 55593

UniProt: Q96G74