OTUD5 anticorps (AA 300-520)

N° du produit ABIN5027170

L’anticorps anti-OTUD5 Polyclonal Lapin est utilisé pour la détection de OTUD5 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour OTUD5 anticorps (AA 300-520) (ABIN5027170)

Antigène: OTUD5 (OTU Domain Containing 5 (OTUD5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OTUD5 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-OTUD5 anticorps

Épitope: AA 300-520

Réactivité croisée: Souris

Purification: Protein A Chromatography

Immunogène: A partial length recombinant DUBA protein (amino acids 300-520) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur OTUD5

Antigène: OTUD5 (OTU Domain Containing 5 (OTUD5))

Autre désignation: DUBA

Sujet: DUBA belongs to a subfamily of 14 DUBs characterized by an OTU (Ovarian Tumor) domain. This protein suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. DUBA forms a direct complex with p53 and controls level of ubiquitination. The function of DUBA is required to allow the rapid activation of p53-dependent transcription and a p53-dependent apoptosis in response to DNA damage stress.

Poids moléculaire: 62 kDa

ID gène: 55593

UniProt: Q96G74