S1PR1 anticorps (AA 86-382)

N° du produit ABIN5027176

L’anticorps Lapin Polyclonal anti-S1PR1 a été validé pour WB. Il convient pour détecter S1PR1 dans des échantillons de Humain.

Aperçu rapide pour S1PR1 anticorps (AA 86-382) (ABIN5027176)

Antigène: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp S1PR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-S1PR1 anticorps

Épitope: AA 86-382

Purification: Protein A Chromatography

Immunogène: A partial length recombinant Edg-1 protein (amino acids 86-382) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur S1PR1

Antigène: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Autre désignation: SIP1 receptor/Edg-1

Sujet: S1PR1 (Sphingosine-1-phosphate receptor 1) is a G-protein coupled receptor, which binds the bioactive S1P (sphingolipid, sphingosine-1-phosphate) as a high affinity ligand. S1P is present at high levels in blood and lymph, and plays a critical role in the homeostasis of the vascular and immune systems. S1PR1 was originally identified as an abundant transcript in endothelial cells and plays a key role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and vascular maturation. In the immune system, S1PR1 signaling is important in the regulation of lymphocyte migration and trafficking. Inhibition of S1PR1 results in lymphocyte sequestration within lymphoid organs. S1PR1 may also regulate tumor cell functions in some types of B cell lymphoma. Inhibition of S1PR1 expression down regulates signal transducer and activator of transcription 3 activity, leading to inhibition of lymphoma tumor cell growth. S1PR1 signaling in T cells drives Treg accumulation in tumors, limits CD8+ T cell recruitment and activation, and promotes tumor growth.

Poids moléculaire: 42 kDa

ID gène: 1901

UniProt: P21453

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2