DDX58 anticorps (AA 1-220)

N° du produit ABIN5027274

Détail du produit anti-DDX58 anticorps

Antigène: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Épitope: AA 1-220

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DDX58 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Protein G Chromatography

Immunogène: A partial length recombinant human RIG-I protein (amino acids 1-220) was used as the immunogen for this antibody.

Clone: ABM40B5

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 2-4 μg/mL, IHC: 5 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur DDX58

Antigène: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Autre désignation: RIG-I (DDX58 Produits)

Synonymes: anticorps RIG-I, anticorps RIGI, anticorps RLR-1, anticorps 6430573D20Rik, anticorps C330021E21, anticorps RHIV-1, anticorps RIG-1, anticorps DExD/H-box helicase 58, anticorps DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, anticorps DEXD/H-box helicase 58, anticorps DDX58, anticorps Ddx58

Sujet: RIG-I or Probable ATP-dependent RNA helicase DDX58 or simply DDX58 is a RNA helicase enzyme with two isoforms (106 and 101 kDa). RIG-I belongs to the DEAD/H box family and is involved in several cellular responses including RNA binding and alteration of RNA secondary structure. RIG-1 acts as sensor of viral nucleic acids thus activating a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines. Generally it remains as a monomer but upon activation by viral dsRNA it homomultimerizes and interacts with mitochondria antiviral signaling protein (MAVS/IPS1) which activating a cascade of reactions to produce specific interferon. RIG-1 is mostly expressed in vascular smooth cells.

Poids moléculaire: 106 kDa

ID gène: 23586

UniProt: O95786

Pathways: Activation of Innate immune Response, Hepatitis C