PTH anticorps (AA 1-236)

N° du produit ABIN5027426

Cet anticorps anti-PTH est un anticorps Souris Monoclonal détectant PTH dans IHC et WB. Adapté pour Humain.

Aperçu rapide pour PTH anticorps (AA 1-236) (ABIN5027426)

Antigène: PTH (Parathyroid Hormone (PTH))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PTH est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Clone: ABM4D44

Détail du produit anti-PTH anticorps

Épitope: AA 1-236

Purification: Protein G Chromatography

Immunogène: A partial length recombinant Parathyroid Hormone protein (amino acids 1-236) was used as the immunogen for this antibody

Isotype: IgG2b kappa

Information d'application

Indications d'application: WB: 2-4 μg/mL, IHC: 5 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur PTH

Antigène: PTH (Parathyroid Hormone (PTH))

Autre désignation: Parathyroid Hormone

Classe de substances: Hormone

Sujet: Parathyroid hormone (PTH) produced and secreted by parathyroid glands, maintains mineral homeostasis by regulating calcium and phosphate absorption/reabsorption. It modulates phosphate homeostasis by downregulating Dentin matrix acidic phosphoprotein 1(DMP1) expression via the cAMP/PKA pathway targeting genes/proteins mutually governed by PTH. PTH secretion is characterized by an ultradian rhythm with tonic and pulsatile components. The majority of PTH is secreted in tonic fashion. Changes in the ultradian PTH secretion are correlated with skeletal fragility in primary and secondary osteoporosis. Plasma concentrations of Zn ions levels were significantly correlated with PTH levels. PTH in serum is typical for patients with chronic kidney disease (CKD). The onset of CKD is associated with pathway changes of protein synthesis and metabolism, amino acid metabolism, energy metabolism, and steroid hormone metabolism. Parathyroid hormones are bone-forming agents that have different modes of action on the bone. Lack of PTH in the central nervous system causes Hypoparathyroidism (HPT).

Poids moléculaire: 59 kDa

ID gène: 5745

UniProt: Q03431

Pathways: cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process