Bax Inhibitor 1 anticorps (AA 1-200)

N° du produit ABIN5027485

L’anticorps anti-Bax Inhibitor 1 Monoclonal Souris est utilisé pour la détection de Bax Inhibitor 1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour Bax Inhibitor 1 anticorps (AA 1-200) (ABIN5027485)

Antigène: Bax Inhibitor 1 (TMBIM6) (Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Bax Inhibitor 1 est non-conjugé

Application: Western Blotting (WB)

Clone: ABM20E4

Détail du produit anti-Bax Inhibitor 1 anticorps

Épitope: AA 1-200

Purification: Protein G Chromatography

Immunogène: A partial length recombinant protein of human Bi-1 (amino acids 1-200) was used as an immunogen for this antibody.

Isotype: IgG2b kappa

Information d'application

Indications d'application: WB: 4-6 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur Bax Inhibitor 1

Antigène: Bax Inhibitor 1 (TMBIM6) (Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6))

Autre désignation: Bi-1

Sujet: Bi-1 is an anti-apoptotic protein that inhibits Bax activation and its translocation to the mitochondria. Functionally, BI-1 affects the leakage of Ca2+ ions from the ER. In addition to its anti-apoptotic role, BI-1 also enhances cancer/tumor progression. It belongs to the Bcl-2 family, plays an important role in the mitochondrial apoptosis pathway. Bi-1 over-expression suppresses apoptosis induced by Bax, staurosporine and growth factor deprivation. BI-1 is presumably not needed for the physiological regulation of developmental programmed cell death. The anti-apoptotic mechanism of BI-1 involves the suppression of Bax activation and translocation to mitochondria, preserving the mitochondria membrane potential and mitochondrial morphology, and preventing the activation of post-mitochondrial caspases. BI-1 function is also associated with the regulation of intracellular Ca2+ omeostasis. In several human cancers, including nasopharyngeal carcinoma, its expression was found to be increased, however, up-regulated expression of this protein has been linked to increased cell proliferations.

Poids moléculaire: 30 kDa

ID gène: 7009

UniProt: P55061

Pathways: Response to Water Deprivation, ER-Nucleus Signaling