TAB3 anticorps (AA 1-385)

N° du produit ABIN5027557

L’anticorps Lapin Polyclonal anti-TAB3 a été validé pour WB. Il convient pour détecter TAB3 dans des échantillons de Humain.

Aperçu rapide pour TAB3 anticorps (AA 1-385) (ABIN5027557)

Antigène: TAB3 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 3 (TAB3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TAB3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TAB3 anticorps

Épitope: AA 1-385

Purification: Protein A Chromatography

Immunogène: A partial length recombinant TAB3 protein (amino acids 1-350) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 4-6 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur TAB3

Antigène: TAB3 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 3 (TAB3))

Autre désignation: TAB3

Sujet: TAB3 (TGF-beta activated kinase 1/MAP3K7 binding protein 3) has CUE domain and RanBP2-type zinc finger (NZF) domains mediates binding to two consecutive 'Lys-63'-linked ubiquitins. It contains 712 amino acids. TAB3 is a mediator of MAP3K7 activation and it forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation of TNF or IL-1. This successive MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor and AP1 transcription factor. This protein shows interaction with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. It has 2 isoforms produced by alternative splicing. Isoform 2 may be an oncogenic factor. TAB3 involved in necrosis and tumors like disease.

Poids moléculaire: 80 kDa

ID gène: 257397

UniProt: Q8N5C8

Pathways: Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades