TXNIP anticorps (AA 50-300)

N° du produit ABIN5027615

Cet anticorps anti-TXNIP est un anticorps Lapin Polyclonal détectant TXNIP dans WB. Adapté pour Humain.

Aperçu rapide pour TXNIP anticorps (AA 50-300) (ABIN5027615)

Antigène: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TXNIP est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TXNIP anticorps

Épitope: AA 50-300

Purification: Protein A Chromatography

Immunogène: A partial length recombinant TxNIP protein (amino acids 50-300) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 1-3 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur TXNIP

Antigène: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Autre désignation: TxNIP/VDUP1

Sujet: TXNIP (thioredoxin interacting protein) inhibits thioredoxin activity by limiting its bioavailability in response to oxidative stress. TXNIP restores COPS5-induced suppression of CDKN1B stability by interacting with COPS5 and blocks the COPS5-mediated translocation of CDKN1B from nucleus to the cytoplasm. TXNIP functions as a transcriptional repressor. TXNIP has been reported to be a suppressor of tumor cell growth and inhibits the proteasomal degradation of DDIT4, contributing to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). TXNIP is expresed in adipose tissue, adrenal cortex, adrenal gland, amniotic fluid and amygdale.

Poids moléculaire: 44 kDa

ID gène: 10628

UniProt: Q9H3M7

Pathways: Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome