VAV2 anticorps (AA 610-824)
-
- Antigène Voir toutes VAV2 Anticorps
- VAV2 (Vav 2 Guanine Nucleotide Exchange Factor (VAV2))
-
Épitope
- AA 610-824
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp VAV2 est non-conjugé
-
Application
- Western Blotting (WB)
- Purification
- Protein A Chromatography
- Immunogène
- A partial length recombinant VAV2 protein (amino acids 610-824) was used as the immunogen for this antibody.
- Isotype
- IgG
- Top Product
- Discover our top product VAV2 Anticorps primaire
-
-
- Indications d'application
- WB: 1-2 μg/mL
- Restrictions
- For Research Use only
-
- Concentration
- 0.5 mg/mL
- Buffer
- PBS containing 0.05 % BSA, PH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
-
- Antigène
- VAV2 (Vav 2 Guanine Nucleotide Exchange Factor (VAV2))
- Autre désignation
- VAV2 (VAV2 Produits)
- Synonymes
- anticorps VAV-2, anticorps 2810040F13Rik, anticorps AI847175, anticorps vav guanine nucleotide exchange factor 2, anticorps vav 2 oncogene, anticorps VAV2, anticorps Vav2
- Sujet
- Vav2 is a member of the Vav family that serves as a GRF (guanine nucleotide exchange factor) for the Rho family of Ras-related GTPases. It is widely expressed and regulates processes including cell migration, neuronal development and phagocytosis through interactions with different proteins. Vav2, a GEF for Rac1, RhoA, and Cdc42, is shown to be regulated by a phosphorylation-dependent interaction with PKL (Paxillin kinase linker). PKL is required for Vav2 activation downstream of integrin engagement and epidermal growth factor (EGF) stimulation. During the process of spinal neurons, the Vav2 activity is necessary for optimal neurite outgrowth and promotes branching by targeting GEF activity to branch points.
- Poids moléculaire
- 90 kDa
- ID gène
- 7410
- UniProt
- P52735
- Pathways
- Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
-