VAV2 anticorps (AA 610-824)

N° du produit ABIN5027629

Détail du produit anti-VAV2 anticorps

Antigène: VAV2 (Vav 2 Guanine Nucleotide Exchange Factor (VAV2))

Épitope: AA 610-824

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VAV2 est non-conjugé

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogène: A partial length recombinant VAV2 protein (amino acids 610-824) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 1-2 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur VAV2

Antigène: VAV2 (Vav 2 Guanine Nucleotide Exchange Factor (VAV2))

Autre désignation: VAV2 (VAV2 Produits)

Synonymes: anticorps VAV-2, anticorps 2810040F13Rik, anticorps AI847175, anticorps vav guanine nucleotide exchange factor 2, anticorps vav 2 oncogene, anticorps VAV2, anticorps Vav2

Sujet: Vav2 is a member of the Vav family that serves as a GRF (guanine nucleotide exchange factor) for the Rho family of Ras-related GTPases. It is widely expressed and regulates processes including cell migration, neuronal development and phagocytosis through interactions with different proteins. Vav2, a GEF for Rac1, RhoA, and Cdc42, is shown to be regulated by a phosphorylation-dependent interaction with PKL (Paxillin kinase linker). PKL is required for Vav2 activation downstream of integrin engagement and epidermal growth factor (EGF) stimulation. During the process of spinal neurons, the Vav2 activity is necessary for optimal neurite outgrowth and promotes branching by targeting GEF activity to branch points.

Poids moléculaire: 90 kDa

ID gène: 7410

UniProt: P52735

Pathways: Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway