CBFB anticorps (N-Term)

N° du produit ABIN5514455

Cet anticorps anti-CBFB Polyclonal Lapin (ABIN5514455) détecte spécifiquement CBFB dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Cheval, Chien, Lapin et Cobaye.

Aperçu rapide pour CBFB anticorps (N-Term) (ABIN5514455)

Antigène: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval, Chien, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBFB est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CBFB anticorps

Épitope: N-Term

Fonction: CBFB Antibody - N-terminal region

Séquence: CRDGRSEIAF VATGTNLSLQ FFPASWQGEQ RQTPSREYVD LEREAGKVYL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PEBB. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human PEBB

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP31417-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur CBFB

Antigène: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Autre désignation: CBFB

Sujet:

Background Information: The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit, it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: core-binding factor subunit beta

Alternative Symbols: PEBP2B

Protein Name: core-binding factor subunit beta

Poids moléculaire: 20kDa

ID gène: 865

UniProt: Q13951

Pathways: Regulation of Lipid Metabolism by PPARalpha