CBFB anticorps (Internal Region)

N° du produit ABIN6655308

Détail du produit anti-CBFB anticorps

Antigène: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBFB est non-conjugé

Application: ELISA, Chromatin Immunoprecipitation (ChIP)

Purification: Anti-CBFb Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. This product reacts with human CBFb.  Cross reactivity with CBFb from other sources is not known.

Immunogène:

Immunogen: Anti-CBFb Antibody was produced in rabbits by repeated immunizations with human CBFb using two synthetic peptides containing sequences from the internal region of the protein.

Immunogen Type: Peptide

Information d'application

Indications d'application:

Application Note: Anti-CBFb Antibody is suitable for Chromatin Immunoprecipitation and ELISA. Specific conditions for reactivity should be optimized by the end user.

ChIP Dilution: 4 μL/ChIP

ELISA Dilution: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

0.01 % (w/v) Sodium Azide

Stabilizer: None

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: RT,4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Détails sur CBFB

Antigène: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Autre désignation: CBFb (CBFB Produits)

Synonymes: anticorps PEBP2B, anticorps Cbfb, anticorps pebp2b, anticorps Pebp2, anticorps CBFB, anticorps unp1266, anticorps cbf-beta, anticorps cbfbeta, anticorps pea2-beta, anticorps pebp2-beta, anticorps AI893578, anticorps PEA2, anticorps PEBP2b, anticorps Pebpb2, anticorps core-binding factor beta subunit, anticorps core binding factor beta subunit, anticorps core-binding factor, beta subunit, anticorps core-binding factor, beta subunit S homeolog, anticorps core binding factor beta, anticorps CBFB, anticorps Cbfb, anticorps cbfb, anticorps cbfb.S

Sujet:

Synonyms: Core-binding factor subunit beta, CBF-beta, Polyomavirus enhancer-binding protein 2 beta subunit, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit

Background: CBFb represents the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family. These transcription factors regulate a host of genes specific to haematopoiesis (e.g. RUNX1) and osteogenesis (e.g. RUNX2). The beta subunit is the regulatory subunit which allosterically enhances the activity of the DNA binding alpha subunit as the complex binds to the core site of various enhancers and promoters. CBFb can be involved in a chromosomal rearrangement of chromosome 16 (inv(16)(p13q22)) which produces a fusion protein consisting of the N terminus of CBFb and the C-terminal portion of MYH11. This chromosomal rearrangement is associated with acute myeloid leukaemia of the M4Eo subtype. Anti-CBFb Antibody is ideal for research in Gene Expression, Cell Differentiation and Cancer.

Gene Name: CBFB

ID gène: 12400

NCBI Accession: NP_001154928

UniProt: Q08024

Pathways: Regulation of Lipid Metabolism by PPARalpha