Cathepsin F anticorps (C-Term)

N° du produit ABIN5514658

L’anticorps anti-Cathepsin F Polyclonal Lapin est utilisé pour la détection de Cathepsin F dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour Cathepsin F anticorps (C-Term) (ABIN5514658)

Antigène: Cathepsin F (CTSF)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cathepsin F est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Cathepsin F anticorps

Épitope: C-Term

Fonction: CTSF Antibody - C-terminal region

Séquence: PLRPLCSPWL IDHAVLLVGY GNRSDVPFWA IKNSWGTDWG EKGYYYLHRG

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human CTSF

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP78433-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Cathepsin F

Antigène: Cathepsin F (CTSF)

Autre désignation: CTSF

Sujet:

Background Information: Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.

Gene Name: cathepsin F

Alternative Symbols: CATSF, CLN13

Protein Name: cathepsin F

Poids moléculaire: 53 kDa

ID gène: 8722

NCBI Accession: NP_003784

UniProt: Q9UBX1