ALIX anticorps (C-Term)

N° du produit ABIN5514748

L’anticorps Lapin Polyclonal anti-ALIX a été validé pour WB. Il convient pour détecter ALIX dans des échantillons de Humain.

Aperçu rapide pour ALIX anticorps (C-Term) (ABIN5514748)

Antigène: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALIX est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ALIX anticorps

Épitope: C-Term

Séquence: QMPMPMGYNP YAYGQYNMPY PPVYHQSPGQ APYPGPQQPS YPFPQPPQQS

Attributs du produit: This is a rabbit polyclonal antibody against PDC6I. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PDC6I

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ALIX

Antigène: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Autre désignation: PDC6I

Sujet: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

Alias Symbols: PDCD6IP, AIP1, ALIX, KIAA1375,

Protein Interaction Partner: UBI4, CEP55, UBC, SUMO2, nef, EZH2, IPO9, UBA6, MCTS1, AHCYL1, EZR, UBA1, MAPK1, CHMP4B, gag, UBD, BAG3, RNF11, KEAP1, VCAM1, SH3GL1, CHMP4C, TNIP2, ITGA4, CXCR1, GRB2, HOXA1, PEF1, VPS4B, ABCC1, GPI, PDCD6, F2R, CUL3, ALG2, PTK2B, TUBB, SIRT7, SH3KBP1, C

Protein Size: 868

ID gène: 10015

NCBI Accession: NP_037506

UniProt: Q8WUM4

Pathways: Signalisation p53, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation