ALIX anticorps (C-Term)

N° du produit ABIN5514748

L’anticorps anti-ALIX Polyclonal Lapin est utilisé pour la détection de ALIX dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour ALIX anticorps (C-Term) (ABIN5514748)

Antigène: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALIX est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ALIX anticorps

Épitope: C-Term

Fonction: PDCD6IP Antibody - C-terminal region

Séquence: QMPMPMGYNP YAYGQYNMPY PPVYHQSPGQ APYPGPQQPS YPFPQPPQQS

Attributs du produit: This is a rabbit polyclonal antibody against PDC6I. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PDC6I

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP75320-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur ALIX

Antigène: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Autre désignation: PDCD6IP

Sujet:

Background Information: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

Gene Name: programmed cell death 6 interacting protein

Alternative Symbols: AIP1, ALIX, HP95, DRIP4

Protein Name: programmed cell death 6-interacting protein

Poids moléculaire: 95kDa

ID gène: 10015

NCBI Accession: NP_037506

UniProt: Q8WUM4

Pathways: Signalisation p53, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation