PNP anticorps (Middle Region)

N° du produit ABIN5514791

Cet anticorps anti-PNP Polyclonal Lapin (ABIN5514791) détecte spécifiquement PNP dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PNP anticorps (Middle Region) (ABIN5514791)

Antigène: PNP (Purine Nucleoside Phosphorylase (PNP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PNP est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PNP anticorps

Épitope: Middle Region

Fonction: PNP Antibody - middle region

Séquence: IMLIRDHINL PGFSGQNPLR GPNDERFGDR FPAMSDAYDR TMRQRALSTW

Attributs du produit: This is a rabbit polyclonal antibody against PNPH. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Human PNPH

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP75005-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur PNP

Antigène: PNP (Purine Nucleoside Phosphorylase (PNP))

Autre désignation: PNP

Sujet:

Background Information: This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.

Gene Name: purine nucleoside phosphorylase

Alternative Symbols: NP, PUNP, PRO1837

Protein Name: purine nucleoside phosphorylase

Poids moléculaire: 31kDa

ID gène: 4860

NCBI Accession: NP_000261

UniProt: P00491

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Ribonucleoside Biosynthetic Process, Positive Regulation of Response to DNA Damage Stimulus