NANOS2 anticorps (C-Term)

N° du produit ABIN5514981

Cet anticorps Lapin Polyclonal détecte spécifiquement NANOS2 dans WB. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Chien, Chévre, Cobaye, Cheval, Porc et Lapin.

Aperçu rapide pour NANOS2 anticorps (C-Term) (ABIN5514981)

Antigène: NANOS2 (Nanos Homolog 2 (NANOS2))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Chévre, Cobaye, Cheval, Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NANOS2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-NANOS2 anticorps

Épitope: C-Term

Séquence: TPDGVVVCPI LRHYVCPVCG ATGDQAHTLK YCPLNGGQQS LYRRSGRNSA

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against NANOS2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human NANOS2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur NANOS2

Antigène: NANOS2 (Nanos Homolog 2 (NANOS2))

Autre désignation: NANOS2

Sujet: NANOS2 plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. It represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. It maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. It regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. It is required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state.

Alias Symbols: NANOS2, NOS2,

Protein Interaction Partner: CCNDBP1, MAGEA12,

Protein Size: 138

ID gène: 339345

NCBI Accession: NP_001025032

UniProt: P60321

Pathways: Retinoic Acid Receptor Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance