RAD51 anticorps (N-Term)

N° du produit ABIN5515419

Cet anticorps Lapin Polyclonal détecte spécifiquement RAD51 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Cobaye, Cheval, Lapin et Chien.

Aperçu rapide pour RAD51 anticorps (N-Term) (ABIN5515419)

Antigène: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye, Cheval, Lapin, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAD51 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RAD51 anticorps

Épitope: N-Term

Séquence: QLEANADTSV EEESFGPQPI SRLEQCGINA NDVKKLEEAG FHTVEAVAYA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 94%, Human: 100%, Mouse: 100%, Rabbit: 94%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against RAD51. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human RAD51

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RAD51

Antigène: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Autre désignation: RAD51

Sujet: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.

Alias Symbols: Name=RAD51,

Protein Interaction Partner: BRCA1, ATRX, FBXO18, PALB2, HNRNPC, SWSAP1, HNRNPA2B1, RPA3, RPA1, RAD52, PFN1, RAD54B, AICDA, BLM, DMC1, NXF1, RECQL5, UGDH, CHEK1, BRCA2, SFR1, SWI5, NEDD8, PML, TERF2IP, TP53, MSH2, MSH6, UBC, UHRF2, RAD51AP1, WRN, POLN, MORF4L1, MDC1, RAD51C, MCPH1, S

Protein Size: 339

ID gène: 5888

UniProt: Q06609

Pathways: Réparation de l'ADN