ADD2 anticorps (C-Term)
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- Antigène Voir toutes ADD2 Anticorps
- ADD2 (Adducin 2 (Beta) (ADD2))
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Épitope
- C-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ADD2 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- SAGPQSQLLA SVIAEKSRSP STESQLMSKG DEDTKDDSEE TVPNPFSQLT
- Attributs du produit
- This is a rabbit polyclonal antibody against ADDB. It was validated on Western Blot.
- Purification
- Affinity purified
- Immunogène
- The immunogen for Anti-ADD2 antibody is: synthetic peptide directed towards the C-terminal region of Human ADDB
- Top Product
- Discover our top product ADD2 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- ADD2 (Adducin 2 (Beta) (ADD2))
- Autre désignation
- ADD2 (ADD2 Produits)
- Synonymes
- anticorps si:dkey-202n14.5, anticorps ADDB, anticorps 2900072M03Rik, anticorps add97, anticorps beta-ADD, anticorps adducin 2, anticorps adducin 2 (beta), anticorps ADD2, anticorps add2, anticorps Add2
- Sujet
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Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described.
Alias Symbols: ADDB,
Protein Size: 726 - ID gène
- 119
- UniProt
- P35612
- Pathways
- Regulation of Actin Filament Polymerization
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