PTAFR anticorps (N-Term)

N° du produit ABIN5515515

Cet anticorps Lapin Polyclonal détecte spécifiquement PTAFR dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PTAFR anticorps (N-Term) (ABIN5515515)

Antigène: PTAFR (Platelet-Activating Factor Receptor (PTAFR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTAFR est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PTAFR anticorps

Épitope: N-Term

Fonction: PTAFR Antibody - N-terminal region

Séquence: EPHDSSHMDS EFRYTLFPIV YSIIFVLGVI ANGYVLWVFA RLYPCKKFNE

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PTAFR

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP76511-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur PTAFR

Antigène: PTAFR (Platelet-Activating Factor Receptor (PTAFR))

Autre désignation: PTAFR

Sujet:

Background Information: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.

Gene Name: Platelet-activating factor receptor

Alternative Symbols: PAFR

Protein Name: platelet-activating factor receptor

Poids moléculaire: 39 kDa

ID gène: 5724

NCBI Accession: NP_000943

UniProt: P25105

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin