RASA1 anticorps (N-Term)

N° du produit ABIN5516840

Cet anticorps anti-RASA1 est un anticorps Lapin Polyclonal détectant RASA1 dans WB. Adapté pour Humain.

Aperçu rapide pour RASA1 anticorps (N-Term) (ABIN5516840)

Antigène: RASA1 (RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RASA1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RASA1 anticorps

Épitope: N-Term

Séquence: GTVDEGDSLD GPEYEEEEVA IPLTAPPTNQ WYHGKLDRTI AEERLRQAGK

Attributs du produit: This is a rabbit polyclonal antibody against RASA1. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human RASA1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RASA1

Antigène: RASA1 (RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))

Autre désignation: RASA1

Sujet: The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.

Alias Symbols: RASA1, GAP, RASA,

Protein Interaction Partner: ARHGAP35, DOK1, KHDRBS1, DOK2, PLCG1, EGFR, ABL1, Mbp, ERBB4, ERBB3, ERBB2, APP, SOCS1, UBC, SPSB1, ZNF579, BBS10, TRMT2A, EIF1, SERPINA4, XRCC6, EZH2, NCK1, BTRC, NFKBIA, DOK4, AFAP1L2, DNAJA3, G3BP1, PAG1, AURKB, MAP4K4, SOCS3, BIRC5, ARHGAP1, ARHGAP5,

Protein Size: 1047

ID gène: 5921

UniProt: P20936

Pathways: Regulation of Actin Filament Polymerization, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals