Spindlin 1 anticorps (N-Term)

N° du produit ABIN5516939

Cet anticorps anti-Spindlin 1 Polyclonal Lapin (ABIN5516939) détecte spécifiquement Spindlin 1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Porc, Boeuf (Vache), Chien et Lapin.

Aperçu rapide pour Spindlin 1 anticorps (N-Term) (ABIN5516939)

Antigène: Spindlin 1 (SPIN1)

Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Chien, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Spindlin 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Spindlin 1 anticorps

Épitope: N-Term

Fonction: SPIN1 Antibody - N-terminal region

Séquence: KTPFGKTPGQ RSRADAGHAG VSANMMKKRT SHKKHRSSVG PSKPVSQPRR

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SPIN1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SPIN1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP52247-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Spindlin 1

Antigène: Spindlin 1 (SPIN1)

Autre désignation: SPIN1

Sujet:

Background Information: SPIN1 is a chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006).It may play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

Gene Name: spindlin 1

Alternative Symbols: SPIN, TDRD24

Protein Name: Spindlin-1

Poids moléculaire: 28kDa

ID gène: 10927

NCBI Accession: NP_006708

UniProt: Q9Y657