MC1 Receptor anticorps (N-Term)

N° du produit ABIN5517430

L’anticorps anti-MC1 Receptor Polyclonal Lapin est utilisé pour la détection de MC1 Receptor dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour MC1 Receptor anticorps (N-Term) (ABIN5517430)

Antigène: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MC1 Receptor est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MC1 Receptor anticorps

Épitope: N-Term

Séquence: QRRLLGSLNS TPTAIPQLGL AANQTGARCL EVSISDGLFL SLGLVSLVEN

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human MC1R

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MC1 Receptor

Antigène: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Autre désignation: MC1R

Sujet: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

Alias Symbols: CMM5, MSH-R, SHEP2

Protein Size: 317

ID gène: 4157

NCBI Accession: NM_002386, NP_002377

UniProt: Q01726

Pathways: cAMP Metabolic Process, Feeding Behaviour