RASGRP1 anticorps (Middle Region)

N° du produit ABIN5517466

L’anticorps anti-RASGRP1 Polyclonal Lapin est utilisé pour la détection de RASGRP1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour RASGRP1 anticorps (Middle Region) (ABIN5517466)

Antigène: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RASGRP1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RASGRP1 anticorps

Épitope: Middle Region

Séquence: GLCHSSISRL KETSSHVPHE INKVLGEMTE LLSSSRNYDN YRRAYGECTD

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human RASGRP1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RASGRP1

Antigène: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Autre désignation: RASGRP1

Sujet: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).

Alias Symbols: V, RASGRP, hRasGRP1, CALDAG-GEFI, CALDAG-GEFII

Protein Size: 797

ID gène: 10125

NCBI Accession: NM_001128602, NP_001122074

UniProt: O95267

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway