HYAL1 anticorps (C-Term)

N° du produit ABIN5518712

Cet anticorps anti-HYAL1 est un anticorps Lapin Polyclonal détectant HYAL1 dans WB. Adapté pour Souris.

Aperçu rapide pour HYAL1 anticorps (C-Term) (ABIN5518712)

Antigène: HYAL1 (Hyaluronidase-1 (HYAL1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HYAL1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-HYAL1 anticorps

Épitope: AA 434-450, C-Term

Fonction: Anti-Hyaluronidase-1 HYAL1 Antibody Picoband®

Séquence: LKDRAQMAMK FRCRCYR

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Hyaluronidase-1 HYAL1 Antibody (ABIN5518712). Tested in WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of mouse HYAL1, different from the related rat sequence by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Mouse
1. Csoka, A. B., Frost, G. I., Heng, H. H. Q., Scherer, S. W., Mohapatra, G., Stern, R. The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor suppressor locus. Genomics 48: 63-70, 1998. Note: Erratum: Genomics 84: 227 only, 2004. 2. Martin, D. C., Atmuri, V., Hemming, R. J., Farley, J., Mort, J. S., Byers, S., Hombach-Klonisch, S., Csoka, A. B., Stern, R., Triggs-Raine, B. L. A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritis. Hum. Molec. Genet. 17: 1904-1915, 2008. Note: Erratum: Hum. Molec. Genet. 17: 2919 only, 2008.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide, Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur HYAL1

Antigène: HYAL1 (Hyaluronidase-1 (HYAL1))

Autre désignation: HYAL1

Sujet:

Synonyms: Hyaluronidase-1,Hyal-1,3.2.1.35,Hyaluronoglucosaminidase-1,Hyal1,

Tissue Specificity: Highly expressed in liver, kidney, lung and skin. .

Background: Hyaluronidase-1, also known as HYAL1 or LUCA1, is an enzyme that in humans is encoded by the HYAL1 gene. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is though to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.

Sequence Similarities: Belongs to the glycosyl hydrolase 56 family.

Poids moléculaire: 60 kDa

Pathways: Glycosaminoglycan Metabolic Process