ARNTL anticorps (AA 58-156)

N° du produit ABIN5518808

Cet anticorps anti-ARNTL Polyclonal Lapin (ABIN5518808) détecte spécifiquement ARNTL dans WB et FACS. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour ARNTL anticorps (AA 58-156) (ABIN5518808)

Antigène: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ARNTL est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-ARNTL anticorps

Épitope: AA 58-156

Fonction: Anti-BMAL1/ARNTL Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-BMAL1/ARNTL Antibody (ABIN5518808). Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human BMAL1/ARNTL recombinant protein (Position: H58-D156). Human BMAL1/ARNTL shares 99% and 98% amino acid (aa) sequence identity with mouse and rat BMAL1/ARNTL, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry(Fixed), 1-3 μg/1x10⁶ cells, Human

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur ARNTL

Antigène: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Autre désignation: ARNTL

Sujet:

Synonyms: Aryl hydrocarbon receptor nuclear translocator-like protein 1,Basic-helix-loop-helix-PAS protein MOP3,Brain and muscle ARNT-like 1,Class E basic helix-loop-helix protein 5,bHLHe5,Member of PAS protein 3,PAS domain-containing protein 3,bHLH-PAS protein JAP3,ARNTL,BHLHE5, BMAL1, MOP3, PASD3,

Tissue Specificity: Hair follicles (at protein level). Highly expressed in the adult brain, skeletal muscle and heart. .

Background: Aryl hydrocarbon receptor nuclear translocator-like protein 1 is protein that in humans is encoded by the ARNTL gene. The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 75 kDa

ID gène: 406

UniProt: O00327

Pathways: Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, L'effet Warburg