BIN1 anticorps (AA 360-389)

N° du produit ABIN5530529

Cet anticorps Lapin Polyclonal détecte spécifiquement BIN1 dans WB et IHC (p). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour BIN1 anticorps (AA 360-389) (ABIN5530529)

Antigène: BIN1 (Bridging Integrator 1 (BIN1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BIN1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-BIN1 anticorps

Épitope: AA 360-389

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This BIN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-389 amino acids from the Central region of human BIN1.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.45 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur BIN1

Antigène: BIN1 (Bridging Integrator 1 (BIN1))

Autre désignation: BIN1

Sujet: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Poids moléculaire: 65 kDa

ID gène: 274

UniProt: O00499