HLA-DMB anticorps (AA 104-133)

N° du produit ABIN5532614

Cet anticorps Lapin Polyclonal détecte spécifiquement HLA-DMB dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour HLA-DMB anticorps (AA 104-133) (ABIN5532614)

Antigène: HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA-DMB est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-HLA-DMB anticorps

Épitope: AA 104-133

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This HLA-DMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the Central region of human HLA-DMB.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur HLA-DMB

Antigène: HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Autre désignation: HLA-DMB

Sujet: HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

Poids moléculaire: 29 kDa

ID gène: 3109

UniProt: P28068

Pathways: Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response