CDK8 anticorps (AA 245-272)
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- Antigène Voir toutes CDK8 Anticorps
- CDK8 (Cyclin-Dependent Kinase 8 (CDK8))
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Épitope
- AA 245-272
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CDK8 est non-conjugé
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Application
- Western Blotting (WB)
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogène
- This Mouse Cdk8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-272 amino acids from the Central region of mouse Cdk8.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product CDK8 Anticorps primaire
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- Indications d'application
- For WB starting dilution is: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Antigène
- CDK8 (Cyclin-Dependent Kinase 8 (CDK8))
- Autre désignation
- Cdk8 (CDK8 Produits)
- Synonymes
- anticorps K35, anticorps wu:fk95h11, anticorps cyclin dependent kinase 8, anticorps cyclin-dependent kinase 8, anticorps cyclin-dependent kinase 8 S homeolog, anticorps Cyclin-dependent kinase 8, anticorps cyclin dependent kinase 19, anticorps CDK8, anticorps Cdk8, anticorps cdk8, anticorps cdk8.S, anticorps cdk-8, anticorps CDK19
- Sujet
- Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation (By similarity).
- Poids moléculaire
- 53 kDa
- ID gène
- 264064
- UniProt
- Q8R3L8
- Pathways
- Cycle Cellulaire, Regulation of Lipid Metabolism by PPARalpha
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