IL13 Receptor alpha 1 anticorps (Extracellular Domain)

N° du produit ABIN5540413

Cité dans 4 publications. Cet anticorps anti-IL13 Receptor alpha 1 Monoclonal Souris (Clone GM1C8) (ABIN5540413) détecte spécifiquement IL13 Receptor alpha 1 dans ICC, IF, FACS et EIA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour IL13 Receptor alpha 1 anticorps (Extracellular Domain) (ABIN5540413)

Antigène: IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL13 Receptor alpha 1 est non-conjugé

Application: Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: GM1C8

Détail du produit anti-IL13 Receptor alpha 1 anticorps

Épitope: Extracellular Domain

Specificité: Clone GM1C8 recognises IL-13Rα1 transiently expressed on the cell surface of transfected BOSC cells as well as the native protein on monocytes (W. Luttmann, unpublished data). Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells. Species: Human.

Purification: Protein G chromatography

Immunogène: cDNA of the human IL-13Ralpha1 chain extracellular domain (U62858).

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: 1.2 μg/10 6 cells. The antibody is routinely tested by on BOSC cells transiently transfected with an IL-13Rα1 expression vector. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. It is expected that the antibody will be suited for all applications where recognition of the native protein is required.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.2 Preservatives: 0.01 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Références pour anticorps anti-IL13 Receptor alpha 1 (ABIN5540413)

Bizzarro, Fontanella, Carratù, Belvedere, Marfella, Parente, Petrella: "Annexin A1 N-terminal derived peptide Ac2-26 stimulates fibroblast migration in high glucose conditions." dans: PLoS ONE, Vol. 7, Issue 9, pp. e45639, (2013) (PubMed).

Thomas, Zhu, Schnaar, Alves, Konstantopoulos: "Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow." dans: The Journal of biological chemistry, Vol. 283, Issue 23, pp. 15647-55, (2008) (PubMed).

Kunii, Nemoto, Kanaya, Tsubahara, Shimauchi: "Expression of CD13/aminopeptidase N on human gingival fibroblasts and up-regulation upon stimulation with interleukin-4 and interleukin-13." dans: Journal of periodontal research, Vol. 40, Issue 2, pp. 138-46, (2005) (PubMed).

Bade, Lohrmann, ten Brinke, Wolbink, Wolbink, ten Berge, Virchow, Luttmann, Hack: "Detection of soluble human granzyme K in vitro and in vivo." dans: European journal of immunology, Vol. 35, Issue 10, pp. 2940-8, (2005) (PubMed).

Détails sur IL13 Receptor alpha 1

Antigène: IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))

Autre désignation: cd213a1,il13ra1

Sujet: Interleukin 13 (IL-13) is a T cell derived cytokine involved in the regulation of inflammatory and im-mune responses. IL-13Rα1 together with IL-4Rα forms a functional receptor for both IL-4 and IL-13, which is why these two cytokines share many of their biological activities. The receptor is found on human B cells, monocytes and endothelial cells. However, no functional receptor is expressed on T cells, which explains why IL-13, in contrast to IL-4, fails to induce TH2-cell differentiation.

UniProt: P78552

Pathways: Signalistation JAK/STAT, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response