CBX1 anticorps

N° du produit ABIN5540983

Cet anticorps anti-CBX1 est un anticorps Souris Monoclonal détectant CBX1 dans IHC (p). Adapté pour Humain, Souris et Porc.

Aperçu rapide pour CBX1 anticorps (ABIN5540983)

Antigène: CBX1 (Chromobox Homolog 1 (CBX1))

Reactivité: Humain, Souris, Porc

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CBX1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1MOD-1A9

Détail du produit anti-CBX1 anticorps

Specificité: This antibody detects HP1β.

Purification: Purified

Immunogène: Recombinant mouse HP1beta

Isotype: IgG1

Information d'application

Indications d'application: Immunohistochemistry on paraffin sections: 4 μg/mL (1:50). Microwave pretreatment in citrate buffer is recommended for antigen retrieval. Suggested Positive control: Human / Swine brain cortex.

Restrictions: For Research Use only

Stockage

Buffer: Buffer System: Phosphate buffered saline pH 7.2 (PBS) Preservatives: 0.01 % Kathon Stabilizers: 5 mg/mL bovine serum albumin (BSA)

Stock: 4 °C,-20 °C

Stockage commentaire: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CBX1

Antigène: CBX1 (Chromobox Homolog 1 (CBX1))

Autre désignation: cbx1

Sujet: Heterochromatin Protein 1 (HP1) (Chromobox Homolog, CBX) includes three isoforms in mammals, designated α, β, and γ. HP1 proteins are approximately 25 kDa in size. They are highly conserved adapter proteins with important regulatory functions in the cell nucleus. These functions include notably gene silencing by heterochromatin formation. HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all Eukaryotic chromosomes. HP1 β and γ also localize to euchromatic sites in the genome. Members of the HP1 family are characterized by an N-terminal chromodomain and a C- terminal chromoshadow domain, separated by a Hinge region. Chromodomain and chromoshadow domain establish secondary interactions with a large number of other proteins. HP1 proteins are subject to multiple types of post - translational modifications, including phosphorylation, acetylation, methylation, ubiquitination and sumoylation, suggesting multiple means of regulation.

UniProt: P83916