CCRL2 anticorps

N° du produit ABIN5541108

L’anticorps anti-CCRL2 Monoclonal Souris est utilisé pour la détection de CCRL2 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour CCRL2 anticorps (ABIN5541108)

Antigène: CCRL2 (Chemokine (C-C Motif) Receptor-Like 2 (CCRL2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CCRL2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1B2

Détail du produit anti-CCRL2 anticorps

Specificité: This antibody detects human CCRL2.

Purification: Protein G

Immunogène: DNA vaccine

Isotype: IgG2a

Information d'application

Indications d'application: Immunohistochemistry on paraffin sections: 4-8 μg/mL (1/50-1/100). Positive control: Human placenta.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline pH 7.2 (PBS) Preservatives: 0.1 % Kathon Stabilizers: 5 mg/mL bovine serum albumin (BSA)

Stock: 4 °C,-20 °C

Stockage commentaire: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CCRL2

Antigène: CCRL2 (Chemokine (C-C Motif) Receptor-Like 2 (CCRL2))

Autre désignation: ccrl2,ccr11

Sujet: Lipopolysaccharide-inducible CC chemokine receptor (LCCR), or CCRL2 is a 344 amino acid protein that belongs to the G - protein coupled receptor 1 family, with a potential glycosylation site and one disulfide bond. CCRL2 is e xp ressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow, but also in lung and heart. CCRL2 is e xpressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T - cells (both CD4+ and CD8+), monocyte - de rived iDCs, NK cells, and CD34+ progenitor cells, and also on glial cells and mast cells at inflammatory sites. It has been reported to be up - regulated on synovial neutrophils of rheumatoid arthritis patients. Unlike other known G - protein coupled receptors, binding of an agonist such as CCL5 or CCL19 does not induce signal transduction through CCRL2. Rather, the ligand is absorbed after binding, and the receptor recycled, thus reducing the local ligand concentration. The leukocyte chemoattractant chemerin is a ligand for CCRL2 as well, but rather than being recycled, the complex seems to promote bridging to the chemerin receptor on nearby cells.

UniProt: O00421